Even though the Colts have dominated the series with an 8-3 edge since 2005, the Jaguars appear to match up well against them and the last six games have been decided by seven points or less.
And the Jaguars shredded the Colts with their running game, 44-17, in 2006 although the Colts went on to win the Super Bowl that year.
The Jaguars won the first game this year on Oct. 5 by a 31-28, on Josh Scobee's 59-yard field goal at the buzzer.
So now their challenge is to sweep the Colts, which they've never done in the past.
The Jaguars had a 174-56 edge in rushing in the first game and figure to be able to run on the Colts' run defense, which is ranked 29th in the league.
Also, quarterback Peyton Manning has been struggling this year and has thrown 15 interceptions, 11 in a three-game stretch. And the Colts have been ravaged by injuries.
Del Rio, though, didn't want to concede that the Jaguars match up well against them.
"I don't know anybody is good at matching up with No. 18 (Manning) back there. He's awfully good at what he does. (Dwight) Freeney and (Robert) Mathis are awfully good at what they do. They've got some real star power. We'll get prepared to go up there and fight as a team. We just want to be the better team on Sunday, but we recognize they're the reigning division champs. They've been on top for a long time. They've earned that; we've got a lot of work to do," he said.
Even if the Jaguars lose, they might have a shot at a wild-card berth if they win their final two games against Washington and Houston to finish 10-6.
Del Rio, though, didn't want to get into any of those scenarios.
"I'm just really looking at it from the standpoint of win the next game. That's where my focus is," he said. "We've got the Colts up next. Big divisional game and then we'll take it from there."
--The players won't begin preparation for the Colts' game until Wednesday because Tuesday is their normal day off and Del Rio gave them Monday off although he suggested they come in and work out and lift weights.
Defensive tackle Terrance Knighton said Sunday, "You know how that goes. You don't have to be here, but you'd better be here. We all have the same goals."
--The Jaguars gave up 31 points in the 38-31 victory over Oakland and Del Rio said they made a lot of mistakes.
"You can't drop coverage and then miss tackles on a checkdown on third-and-10. With the exception of that play, we were going to be four three-and-outs at the start of the game. We just can't have a lapse like that," he said.
He was referring to Darren McFadden's 67-yard touchdown run with a short pass when Daryl Smith blew the coverage and Sean Considine missed a tackle.
--Del Rio wasn't happy with some of the scuffling the Raiders did in the game.
"It looks like something that might occur in an alley somewhere," he said.
Del Rio grew up a Raiders fan and their style of play didn't bother him then.