The Jaguars have lost their last three Monday night games, their last three Thursday night games and their last Sunday night game.
The Jaguars are desperate for a victory after losing to the Pittsburgh Steelers, 17-13, for their fifth consecutive victory.
Their last prime-time victory came in 2006 when they beat the New York Giants, 26-10.
The Jaguars also have to avoid getting in a hole at the start of games. In four of their first six games, the defense gave up a touchdown on the opponent's first drive.
In two of the games, the opponent scored on its first two drives to take a 14-0 lead. New Orleans did in their fourth game and the Steelers did it last week.
The Jaguars also continued their trend of failing to come up with a big drive at the end after having the ball with a shot to stay in the game. This is the third time in four games they couldn't come up with a big play at the end.
In Carolina, they had ball with 16 seconds left at the Carolina 36. But they weren't lined up at the line of scrimmage when a replay decision was made and got off only one play and the Jaguars lost 16-10.
Against Cincinnati last week, they had the ball at the Jaguars 42 with 1:19 left when Brad Meester snapped the ball before Blaine Gabbert was ready in the shotgun and the Bengals recovered with the Jaguars trailing 23-20.
Against the Steelers, they had the ball at their 48, trailing by a touchdown. But on 4th and 6 at the Pittsburgh 27, they took a field goal to cut the deficit to 17-13. They got the ball back at their 23 with 1:01 left and got to the Pittsburgh 48 as Blaine Gabbert's 48-yard Hail Mary pass fell incomplete.
Coach Jack Del Rio said, "It seems like an awful long way when you're not closing out and finding ways to win. Certainly, there were three games that were very close where we had our moment. We just need to play a little bit better in some key moments. Ultimately, if that doesn't occur, it falls on my shoulders as a head coach and I understand that and take full responsibility for that. Ultimately, I've got to find a way to get our guys to play a little bit better because we're not that far away."